About Lupron Depot

LUPRON DEPOT® (leuprolide acetate for depot suspension) 7.5 mg, −3 Month 22.5 mg and −4 Month 30 mg are prescribed for the palliative treatment of advanced prostate cancer.

An increase in urinary symptoms and/or pain may occur during the first few weeks of LUPRON DEPOT treatment. In patients whose cancer has spread to the spine or urinary tract, urinary blockage or pressure in the spine may occur and can lead to paralysis, which may be fatal. LUPRON DEPOT may cause impotence. Females who are or may become pregnant should not receive LUPRON DEPOT.

Please click here for additional Important Safety Information you should know about LUPRON DEPOT and discuss with your doctor.

Lupron Depot has been used since 1989 for the palliative treatment of advanced prostate cancer.

Lupron Depot suppresses the production of testosterone by the testicles. This deprives hormone-dependent prostate cancer cells of the hormone (ie, testosterone) they need to grow, causing their growth to slow. Decreasing the amount of testosterone in the body can result in a reduction of symptoms related to advanced prostate cancer, such as bone pain or difficulty in urinating. It is important to remember that Lupron Depot is used for palliative treatment and is not a cure for cancer. Your physician can explain more on how Lupron Depot can specifically help you.

If you or someone you care about has been diagnosed with advanced prostate cancer or if treatment with prostatectomy or radiation therapy has been unsuccessful, Lupron Depot may be an option for you.

One of the most important things you can do is to think of your doctor as a partner in your care. Before doctor visits, spend some time thinking about the questions you’ll want answered. Being prepared in advance can help you talk to your doctor.

Dosage/Length of Therapy

Lupron Depot is an intramuscular injection that gives you and your physician three dosing options:

  • One injection given once every 4 months (i.e. 16 weeks)
    Lupron Depot –4 Month 30 mg
  • One injection given once every 3 months (i.e. 12 weeks)
    Lupron Depot –3 Month 22.5 mg
  • One injection given once a month
    Lupron Depot 7.5 mg

Use and Important Safety Information you should know about Lupron Depot® (leuprolide acetate for depot suspension)


Use

LUPRON DEPOT® (leuprolide acetate for depot suspension) 7.5 mg, −3 Month 22.5 mg and −4 Month 30 mg are prescribed for the palliative treatment of advanced prostate cancer.

Important Safety Information

Do not take LUPRON DEPOT if you have experienced any type of allergic reaction to LUPRON DEPOT or similar drugs.

LUPRON DEPOT 7.5 mg, −3 Month 22.5 mg and −4 Month 30 mg should not be used in women.

An increase in testosterone will generally occur during the first few weeks of therapy. In some men, this may cause a temporary increase in urinary symptoms and/or pain. If your cancer has spread to the spine or urinary tract, you may require close medical attention during the first few weeks of therapy. You should also know that LUPRON DEPOT may cause impotence. You should notify your doctor if you develop any new or worsened symptoms after beginning LUPRON DEPOT treatment.

It is recommended that your PSA and serum testosterone levels be monitored at regular intervals.

The most common side effects of LUPRON DEPOT include hot flashes or sweats, injection site reactions, general pain, edema, testicular atrophy, urinary disorders, joint disorder and GI disorders.

LUPRON DEPOT must be administered in your doctor’s office.

This is the most important information to know about LUPRON DEPOT. For more information, talk with your health care provider.

Reference: LUPRON DEPOT 7.5 mg, −3 Month 22.5 mg and −4 Month 30 mg [package insert]. North Chicago, IL: Abbott Laboratories.

Please see the complete Prescribing Information for Lupron Depot.

Lupron Depot is available by prescription only.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088 (1-800-332-1088).
If you cannot afford your medication, contact www.pparx.org or call the
toll-free phone number (1-888-4PPA-NOW) (1-888-477-2669) for assistance.

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